Epidemics and diseases have spread in Mesopotamia throughout the historical periods, for many reasons, for example, the religious and magic reasons, such as, gods wrath, magic and sorcery activities, and demons, or environmental causes, such as, air and water pollution, or because of the spread of insects and lesions, or disasters, like flood and destruction of cities.etc.., that cause diseases, because of pollution and starvation, moreover, wars and invasions, and the subsequent deterioration of the social and environmental situation, and even health condition, Moreover, economic situation. Infection and the speed that causes diseases, and other preseasons. Cuneiform sources and archaeological excavations were very popular in our knowledge of medicine, those texts mentioned a number of the names of diseases, their reasons, diagnose, and treatments. Our knowledge about medicine increased throughout the historical periods of Mesopotamia until it became very detailed in the first millennium BC. Among the diseases diagnosed by the Mesopotamian doctors is epilepsy.